Products

Cocrystal Screening Kits

We will soon be launching standard kits of predispensed cocrystal formers in GC/LC vials, in a variety of sets of 12 or 24, ready for addition of API for direct use in our Screening mill.Kit Picture These kits contain a wide spectrum of acids, amines, amides, ureas and neutral compounds providing the best possible chance of forming a co-crystal.

  • GRAS set 1: 12 diverse materials that are 'Generally Regarded As Safe' and a good starting point for a screen*
  • GRAS set 2: 12 supplementary materials if a more extensive GRAS screen* is required
  • Supplementary set 3:
  • Supplementary set 4:  sets of additional cocrystal formers for more diversity
  • We will also prepare sets according to customers requirements for screens* or studies**. These may be standard custom sets or 'one-off'

 

*a screen is considered a rapid pass-or-fail test and the cocrystal formers in these screen kits are diverse enough that at least one ís likely to form a cocrystal with your API

**a study is considered an extensive series of tests of stoichiometry, solvent, conditions etc., and kits are prepared accordingly. Alternatively, a customer may already know what class of cocrystal former they would like to test and a set of a variety of compounds in this class may be supplied.

Kits will be provided with relevant chemical information and is expected to include vial weight, powder weight, molecular weight, moles, structure and Raman spectra

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High Throughput Cocrystal Screening

Powder

Automaxion has developed technology (Patent applied for) to perform dry, solvent drop grinding (SDG) or liquid assisted grinding (LAG) for cocrystal screening (48 in parallel possible) all performed in low cost GC vials at the 20 mg scale. Dispensing, processing and measurement is possible without removing the sample from the vial.

Automaxion-Coxtal

Please Click here for a summary of features

Read the article in the International Journal of Pharmaceutics, Volume 411, Issues 1-2, 15 June 2011, Pages 169-171

Or Test the system for free

1/8” Compact pH/Temperature probes

We can supply steel or titanium ‘armored’ combination pH electrodes that incorporate temperature sensors. All in a 1/8” diameter probe. They are ideal for incorporating into multi-reactor systems. Glass electrode of 1/8” diameter overall. Protected from breakage in robotic applications by a titanium or stainless steel sheath. Both reference and temperature sensors are within the electrode. We can supply them to any reasonable length. Ideal for automation application such as mounting in our dual shear mixer.

Multi-Sample Milling

millAutomaxion provides a system that enables  many (32 possible) samples to be milled in parallel with no mill cleaning and makes milling using robotics practical. Please contact us for details. (Patented)

More details and particle size data

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Dual Shear Mixing

dualshearLow shear mixing and high shear homogenization in one package. Allows mounting of 3 tubes or sensors including our armored pH sensors. This allows a single mixer to combine ingredients and then homogenize them without being removed for cleaning. Compatible with robotic systems. 

This patented device is able to mix samples under different shear regimes– Low shear using the external paddles or high shear using the internal homogenizer. Mounting is provided for 3 tubes or sensors of 1/8" diameter. Fully computer controllable. Constant speed with current feedback allows estimation of viscosity.

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